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KMID : 1143420220150332354
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Public Health Weekly Report
2022 Volume.15 No. 33 p.2354 ~ p.2363
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Characteristics of Carbapenem-resistant Enterobacteriaceae (CRE) in the Republic of Korea, 2021
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Jeong Hyo-Seon
Hyun Jung-Hee
Lee Yeon-Kyeng
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Abstract
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Carbapenem-resistant Enterobacteriaceae (CRE) belong to Korea’s national infectious diseases (Category Ⅱ). CRE are
Enterobacteriaceae that are resistant to any carbapenem antimicrobial, and have been reported by mandatory surveillance
systems since June 2017. This study aimed to identify the characteristics of CRE in 2021 by case (as per sex, age group,
medical institution type), species, and carbapenemase genotype. In 2021, a total of 23,311 cases of CRE were reported from 1,067 medical institutions. The number of cases and medical institutions increased each year from 2019 to 2021. Carbapenemase-producing Enterobacteriaceae (CPE), known to affect the spread of CRE, accounted for 63.4% (14,769 cases). 81.1% (18,894 cases) were reported in cases over the age of 60, and 10.2% (2,383 cases) were reported from long-term care hospitals. Among the CRE species, Klebsiella pneumoniae was the most common (68.6%), followed by Escherichia coli (14.3%). As for carbapenemase genotype of CPE, KPC (Klebsiella pneumoniae carbapenemase) accounted for 76.2% (10,914 cases), followed by NDM (New Delhi metallo-β-lactamase) with 19.7% (2,822 cases). More than half of CPE were found in metropolitan areas, and the regional distribution of CPE was different for each carbapenemase genotype. This study showed that, to contain the spread of CRE in Korea, characteristics of CRE and regional distribution of CPE need to be considered. In addition to the national program of strengthening infection control systems, local governments and medical institutions also need to continue multifaceted efforts such as monitoring, transmission blocking, education, and infection control.
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KEYWORD
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Carbapenem-resistant Enterobacteriaceae (CRE), Carbapenemase-producing Enterobacteriaceae (CPE)
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